This is chronic pain that cannot be explained by structural or physiological changes and whose onset or persistence is driven by psychological factors—stress, anxiety, depression, or emotional trauma. The pain is real and can significantly interfere with dailyactivities, quality of life. This pain syndrome is characterized by the fact that it does not respond to treatment with pain medications, pain management interventions, or surgical procedures. Treatment is usually comprehensive, encompassing psychotherapy, and long-term use of specific psychoactive medications.