Long-term use of opioid (narcotic) analgesics may lead to the development of withdrawal syndrome, which occurs failure to take the usual dose of the medication. The patient experiences strongų physicalinto painą, often all bones, muscle, abdominal, chest, suffering from insomnia, nausea, diarrhea, and severe anxiety. You can also ihyperalgesia syndrome may develop, i.e., pincreasea syndrome characterized by hypersensitivity to pain, in whichLong-term opioid use paradoxically increasea the sensation of pain. In that case The same opioids are used to treat pain medications become ineffective and when taking them or increasing the dose, the pain only gets worse. Psychological dependence often occurs alongside it as wellpsychological dependence – aa constant need to use opioid medications to avoid pain and feel “normal”.